Liposomal drug delivery systems an updated review pdf Georgian Sands Beach
A dual-mediated liposomal drug delivery system targeting Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use.
A two-component drug delivery system using Her-2-targeting
A two-component drug delivery system using Her-2-targeting. In this review article, we discussed about liposome, these are one amongst the various drug delivery system used to target the drug to particular tissue. Because Because of structure similarity between lipid bilayer & cell membrane, liposome can penetrate effectively deliver drug to such that a free drug would not penetrate., 1/12/2015 · Types of liposomal drug delivery platforms. In general, there are four key types of liposomal delivery systems—conventional liposomes, sterically-stabilized liposomes, ligand-targeted liposomes, and a combination of the above (Figure (Figure1). 1)..
Expert Review Functionalized Micellar Systems for Cancer Targeted Drug Delivery general use of micelles as drug delivery systems (4Y13). The purpose of this review is to provide an updated, comprehen-sive review on recent breakthroughs and applications of polymer micelles for tumor-specific therapy. First, a brief overview on micelle structure and composition will be presented, followed by Liposomal Drug Delivery Systems Current Drug Delivery, 2007, Vol. 4, No. 4 303 Liposomes with a small diameter (100 nm) as well as large diameter undergo free diffusion through the Blood Brain Barrier
Here, we present a summary of the latest technologies used to increase cutaneous delivery through the three different routes outlined above, delineating various chemical and physical methods as well as reviewing various drug delivery systems, including liposomes, microspheres, and nanoparticles. REVIEW Open Access Liposomal delivery systems for intestinal lymphatic drug transport Hyeji Ahn and Ji-Ho Park* Abstract Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in
Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online. Liposomes are the simple microscopic vesicles in which aqueous layer is enclosed by phospho lipid bilayers that are used to transfer vaccines ,drugs ,enzymes and other substances to targetcells or organs Structually ,liposomes are concentric bilayerd vesicles in which an aqueous volume is entirely enclosed by a membraneous lipid bilayer mainly composed of natural or synthetic phospholipids
Liposomal Drug Delivery Systems Current Drug Delivery, 2007, Vol. 4, No. 4 299 Ridy et al. [18] prepared oxamniquine liposomes with different compositions and … Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online.
22/02/2013 · Thus, much attention on the use of drug delivery systems is focused on overcoming these problems, ultimately leading to the induction of maximal ability of anti-cancer drug. In this respect, a new model for cancer therapy using a novel drug delivery system, fusogenic liposome [ 45 ], … systems can form closed bilayered structures, lipo-somes have moved a long way from being just another exotic object of biophysical research to become a pharmaceutical carrier of choice for numerous prac-tical applications (FIG. 1; BOX 1).The real breakthrough developments in the area during the past 15 years have resulted in the approval of several liposomal drugs,and the appearance of many
New Developments in Liposomal Drug Delivery Bhushan S. Pattni †, Vladimir V. Chupin ‡ , and Vladimir P. Torchilin * †§ †Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University , … bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use.
Liposomal drug delivery systems – Clinical applications, Acta Pharm. 55 (2005) 1–25. tions. Lack of specificity in pharmacologically active agents is an obstacle to their effective Expert Review Functionalized Micellar Systems for Cancer Targeted Drug Delivery general use of micelles as drug delivery systems (4Y13). The purpose of this review is to provide an updated, comprehen-sive review on recent breakthroughs and applications of polymer micelles for tumor-specific therapy. First, a brief overview on micelle structure and composition will be presented, followed by
Liposomes are the simple microscopic vesicles in which aqueous layer is enclosed by phospho lipid bilayers that are used to transfer vaccines ,drugs ,enzymes and other substances to targetcells or organs Structually ,liposomes are concentric bilayerd vesicles in which an aqueous volume is entirely enclosed by a membraneous lipid bilayer mainly composed of natural or synthetic phospholipids Certainly, the area of in-vitro testing for liposomal drug delivery systems lags behind the advances realised in drug product development. The present review provides an overview of the current compendial and non-compendial methods used for in-vitro release testing of liposomes.
DOI: 10.4103/2230-973X.96920. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Current Drug Delivery, 2007, 4, 297-305 297 Liposomal Drug Delivery Systems: An Update Review Abdus Samad, Y. Sultana* and M. Aqil Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India Abstract: The discovery of liposome or
Liposomal Drug Delivery Systems Current Drug Delivery, 2007, Vol. 4, No. 4 303 Liposomes with a small diameter (100 nm) as well as large diameter undergo free diffusion through the Blood Brain Barrier In 2012 the first report on bio-mimetic drug delivery nano systems was published In 2015 ThermoDox (thermosensitive liposomal doxorubicin) was evaluated in clinical trials (Phase III).
Nanoscale drug delivery systems An updated view. Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online., We report on a new method for enhancing the specificity of drug delivery for tumor cells, using thermosensitive immunoliposomes. The liposomes are conjugated to the antibody trastuzumab (Herceptin), which targets the human epidermal growth factor receptor 2 (Her-2), a cell membrane receptor overexpressed in many human cancers..
Local Drug Delivery Systems in Periodontal Treatment A Review
Liposomal delivery systems for intestinal lymphatic drug. These nano drug delivery systems mainly include liposomes, micelles, solid lipid nanoparticles, nanoemulsions, which are biocompatible and biodegradable nanoparticles. These nanoparticles can increase the stability and aqueous solubility of phytochemicals. They can also be used as sustained drug delivery systems. Much work has also proven that they enhance the absorption and …, A liposome-capsule dosage unit system for the delivery of a biologically active material is formed by encapsulating a biologically active materials in liposomes and then placing the liposome encapsulated material into a capsule..
US20060099243A1 Liposome drug delivery - Google Patents
NANO REVIEW Open Access Liposome classification. REVIEW Open Access Liposomal delivery systems for intestinal lymphatic drug transport Hyeji Ahn and Ji-Ho Park* Abstract Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in This review approaches the main delivery systems for the administrations of the drug to the periodontal pocket, their usefulness as well as advancement of these systems effectiveness in the periodontal therapy. Keywords: Periodontal Diseases, Periodontal Pocket, Local Drug Delivery INTRODUCTION Periodontal disease is a term which involves several pathological conditions range ….
In this review article, we discussed about liposome, these are one amongst the various drug delivery system used to target the drug to particular tissue. Because Because of structure similarity between lipid bilayer & cell membrane, liposome can penetrate effectively deliver drug to such that a free drug would not penetrate. Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online.
A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood-brain barrier, and the transporting mechanism to glioma cells Chang Liu,1,* Xiao-Na Liu,1,* Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Ling-Fei Yang,1 Lan Yuan,2 Ying Xie1 1Beijing Key Laboratory of Molecular Pharmaceutics A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood-brain barrier, and the transporting mechanism to glioma cells Chang Liu,1,* Xiao-Na Liu,1,* Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Ling-Fei Yang,1 Lan Yuan,2 Ying Xie1 1Beijing Key Laboratory of Molecular Pharmaceutics
Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. A dual-mediated liposomal drug delivery system targeting the brain: rational construction, integrity evaluation across the blood-brain barrier, and the transporting mechanism to glioma cells Chang Liu,1,* Xiao-Na Liu,1,* Gui-Ling Wang,1 Yu Hei,1 Shuai Meng,1 Ling-Fei Yang,1 Lan Yuan,2 Ying Xie1 1Beijing Key Laboratory of Molecular Pharmaceutics
Here, we present a summary of the latest technologies used to increase cutaneous delivery through the three different routes outlined above, delineating various chemical and physical methods as well as reviewing various drug delivery systems, including liposomes, microspheres, and nanoparticles. Abstract: The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics.
Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online. Since then, tremendous amounts of papers were published on the uses of liposomes as a drug delivery system (DDS). So, this mini-review is mainly focused on the use of liposome as DDS. So, this mini-review is mainly focused on the use of liposome as DDS.
Background: In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Methods: Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use.
systems can form closed bilayered structures, lipo-somes have moved a long way from being just another exotic object of biophysical research to become a pharmaceutical carrier of choice for numerous prac-tical applications (FIG. 1; BOX 1).The real breakthrough developments in the area during the past 15 years have resulted in the approval of several liposomal drugs,and the appearance of many Conventional liposomal drug delivery has been hampered by short circulation time in blood due to the preferential accumulation of liposomes in organs of RES. In an effort to address this problem, various surface modifying molecules were investigated including synthetic or natural polymers and oligosaccharides, etc. Among these molecules, PEG (PEG, av. MW 2000–5000 Da) is known to be …
bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use. Liposomal drug delivery systems – Clinical applications, Acta Pharm. 55 (2005) 1–25. tions. Lack of specificity in pharmacologically active agents is an obstacle to their effective
Conventional liposomal drug delivery has been hampered by short circulation time in blood due to the preferential accumulation of liposomes in organs of RES. In an effort to address this problem, various surface modifying molecules were investigated including synthetic or natural polymers and oligosaccharides, etc. Among these molecules, PEG (PEG, av. MW 2000–5000 Da) is known to be … Certainly, the area of in-vitro testing for liposomal drug delivery systems lags behind the advances realised in drug product development. The present review provides an overview of the current compendial and non-compendial methods used for in-vitro release testing of liposomes.
This delivery system achieves specific delivery of such biologically-active compounds through associating the compounds with liposomes and proliposome components. In preferred embodiments, the biologically active compound is formulated as a proliposomal composition that can be reconstituted in vivo to provide a liposomal preparation. In this review article, we discussed about liposome, these are one amongst the various drug delivery system used to target the drug to particular tissue. Because Because of structure similarity between lipid bilayer & cell membrane, liposome can penetrate effectively deliver drug to such that a free drug would not penetrate.
Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation Alex Bunker , Aniket Magarkar , Tapani Viitala Since then, tremendous amounts of papers were published on the uses of liposomes as a drug delivery system (DDS). So, this mini-review is mainly focused on the use of liposome as DDS. So, this mini-review is mainly focused on the use of liposome as DDS.
Liposomal Drug Delivery Systems an Update Review
Liposomal Drug Delivery Systems An Update Review Abdus. systems can form closed bilayered structures, lipo-somes have moved a long way from being just another exotic object of biophysical research to become a pharmaceutical carrier of choice for numerous prac-tical applications (FIG. 1; BOX 1).The real breakthrough developments in the area during the past 15 years have resulted in the approval of several liposomal drugs,and the appearance of many, New Developments in Liposomal Drug Delivery Bhushan S. Pattni †, Vladimir V. Chupin ‡ , and Vladimir P. Torchilin * †§ †Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University , ….
Liposomes (a Review) PharmTech
Liposomal Drug Delivery System for Cancer Therapy. Clinical Application of Drug Delivery Systems in Cancer Chemotherapy: Review of the Efficacy and Side Effects of Approved Drugs Takuya Iwamoto Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University; Tsu, Mie 514–8507, Japan. Received December 25, 2012 In recent years, drug delivery systems (DDS) have been developed, along with anticancer agents for those systems, Why use liposomes in drug delivery? Applications of liposome-based formulations and products cover a wide variety of delivery systems as they are able to incorporate a series classes of substances such as anticancer drugs, antiviral, antibacterial, hormones, enzymes, steroids, nucleotides, peptides, proteins and bronchodilators..
The first liposomal drug delivery experiments in humans were carried out by freshly prepared liposomes but in order to be a commercial product the liposome-drug formulation must have well-defined stability and a shelf life over a year. Of the several preparation methods described in the literature, only a few of them have the potential to be used in the large scale liposome … This review approaches the main delivery systems for the administrations of the drug to the periodontal pocket, their usefulness as well as advancement of these systems effectiveness in the periodontal therapy. Keywords: Periodontal Diseases, Periodontal Pocket, Local Drug Delivery INTRODUCTION Periodontal disease is a term which involves several pathological conditions range …
bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use. Rational design of liposomal drug delivery systems, a review: Combined experimental and computational studies of lipid membranes, liposomes and their PEGylation Alex Bunker , Aniket Magarkar , Tapani Viitala
Background: In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Methods: Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels Liposomes are the simple microscopic vesicles in which aqueous layer is enclosed by phospho lipid bilayers that are used to transfer vaccines ,drugs ,enzymes and other substances to targetcells or organs Structually ,liposomes are concentric bilayerd vesicles in which an aqueous volume is entirely enclosed by a membraneous lipid bilayer mainly composed of natural or synthetic phospholipids
bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use. bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use.
Conventional liposomal drug delivery has been hampered by short circulation time in blood due to the preferential accumulation of liposomes in organs of RES. In an effort to address this problem, various surface modifying molecules were investigated including synthetic or natural polymers and oligosaccharides, etc. Among these molecules, PEG (PEG, av. MW 2000–5000 Da) is known to be … Background: In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Methods: Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels
In 2012 the first report on bio-mimetic drug delivery nano systems was published In 2015 ThermoDox (thermosensitive liposomal doxorubicin) was evaluated in clinical trials (Phase III). Since then, tremendous amounts of papers were published on the uses of liposomes as a drug delivery system (DDS). So, this mini-review is mainly focused on the use of liposome as DDS. So, this mini-review is mainly focused on the use of liposome as DDS.
Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online. We report on a new method for enhancing the specificity of drug delivery for tumor cells, using thermosensitive immunoliposomes. The liposomes are conjugated to the antibody trastuzumab (Herceptin), which targets the human epidermal growth factor receptor 2 (Her-2), a cell membrane receptor overexpressed in many human cancers.
Liposomal Drug Delivery Systems Current Drug Delivery, 2007, Vol. 4, No. 4 299 Ridy et al. [18] prepared oxamniquine liposomes with different compositions and … An Updated Review Upendra Bulbake †The concept of liposomal drug delivery system has revolutionised the pharmaceutical field. Alec Bangham, in 1961 [1], first described liposomes. Since then active research in the field of liposomes have been carried out and their applications are now well established in various areas, such as drug, biomolecules and gene delivery [2]. Liposomes are
Liposomal Drug Delivery Systems Current Drug Delivery, 2007, Vol. 4, No. 4 303 Liposomes with a small diameter (100 nm) as well as large diameter undergo free diffusion through the Blood Brain Barrier Since then, tremendous amounts of papers were published on the uses of liposomes as a drug delivery system (DDS). So, this mini-review is mainly focused on the use of liposome as DDS. So, this mini-review is mainly focused on the use of liposome as DDS.
Conventional liposomal drug delivery has been hampered by short circulation time in blood due to the preferential accumulation of liposomes in organs of RES. In an effort to address this problem, various surface modifying molecules were investigated including synthetic or natural polymers and oligosaccharides, etc. Among these molecules, PEG (PEG, av. MW 2000–5000 Da) is known to be … PDF The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of
This delivery system achieves specific delivery of such biologically-active compounds through associating the compounds with liposomes and proliposome components. In preferred embodiments, the biologically active compound is formulated as a proliposomal composition that can be reconstituted in vivo to provide a liposomal preparation. The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics.
In-vitro drug release methods for liposomal drug delivery
Liposomes in Drug Delivery Creative Biostructure. 1/12/2015 · Types of liposomal drug delivery platforms. In general, there are four key types of liposomal delivery systems—conventional liposomes, sterically-stabilized liposomes, ligand-targeted liposomes, and a combination of the above (Figure (Figure1). 1)., These nano drug delivery systems mainly include liposomes, micelles, solid lipid nanoparticles, nanoemulsions, which are biocompatible and biodegradable nanoparticles. These nanoparticles can increase the stability and aqueous solubility of phytochemicals. They can also be used as sustained drug delivery systems. Much work has also proven that they enhance the absorption and ….
Liposomal Drug Delivery Systems From Concept To Clinical. Liposomes are the simple microscopic vesicles in which aqueous layer is enclosed by phospho lipid bilayers that are used to transfer vaccines ,drugs ,enzymes and other substances to targetcells or organs Structually ,liposomes are concentric bilayerd vesicles in which an aqueous volume is entirely enclosed by a membraneous lipid bilayer mainly composed of natural or synthetic phospholipids, In this review article, we discussed about liposome, these are one amongst the various drug delivery system used to target the drug to particular tissue. Because Because of structure similarity between lipid bilayer & cell membrane, liposome can penetrate effectively deliver drug to such that a free drug would not penetrate..
Liposomal Drug Delivery System a Comprehensive Review
NANO REVIEW Open Access Liposome classification. bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use. Drug Delivery Systems - An Update Review - Download as PDF File (.pdf), Text File (.txt) or read online..
New Developments in Liposomal Drug Delivery Bhushan S. Pattni †, Vladimir V. Chupin ‡ , and Vladimir P. Torchilin * †§ †Department of Pharmaceutical Sciences, Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University , … Why use liposomes in drug delivery? Applications of liposome-based formulations and products cover a wide variety of delivery systems as they are able to incorporate a series classes of substances such as anticancer drugs, antiviral, antibacterial, hormones, enzymes, steroids, nucleotides, peptides, proteins and bronchodilators.
Drug delivery systems can provide enhanced efficacy and/or reduced toxicity for anticancer agents. Liposome drug delivery systems are able to modify the pharmacokinetics and biodistribution of cytostatic agents, increasing the concentration of the drug released to neoplastic tissue and reducing the Drug delivery systems can provide enhanced efficacy and/or reduced toxicity for anticancer agents. Liposome drug delivery systems are able to modify the pharmacokinetics and biodistribution of cytostatic agents, increasing the concentration of the drug released to neoplastic tissue and reducing the
These nano drug delivery systems mainly include liposomes, micelles, solid lipid nanoparticles, nanoemulsions, which are biocompatible and biodegradable nanoparticles. These nanoparticles can increase the stability and aqueous solubility of phytochemicals. They can also be used as sustained drug delivery systems. Much work has also proven that they enhance the absorption and … Since then, tremendous amounts of papers were published on the uses of liposomes as a drug delivery system (DDS). So, this mini-review is mainly focused on the use of liposome as DDS. So, this mini-review is mainly focused on the use of liposome as DDS.
bioavailability and delivery of therapeutic agents. Due to innovative developments in liposome technology, numerous liposome Due to innovative developments in liposome technology, numerous liposome based drug delivery systems are currently in clinical trial, and recently some of them have been approved for clinical use. The Sustained release drug delivery efficacy of the liposomal formulation depends on Liposomes can be used to provide a sustained its ability to deliver the drug molecule to the release of drugs. provided the original work is properly cited. the liposome can accommodate peptide derivatives were formulated as liposomes antigens in the aqueous cavity or incorporate and administered systemically
Abstract: The discovery of liposome or lipid vesicle emerged from self forming enclosed lipid bi-layer upon hydration; liposome drug delivery systems have played a significant role in formulation of potent drug to improve therapeutics. We report on a new method for enhancing the specificity of drug delivery for tumor cells, using thermosensitive immunoliposomes. The liposomes are conjugated to the antibody trastuzumab (Herceptin), which targets the human epidermal growth factor receptor 2 (Her-2), a cell membrane receptor overexpressed in many human cancers.
Among several talented new drug delivery systems, liposomes characterize an advanced technology to deliver active molecules to the site of action, and at present, several formulations are in clinical use. DOI: 10.4103/2230-973X.96920. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.
drug delivery system (TDDS) are looked upon as more promising strategies. Accordingly, the first Accordingly, the first example of cell specific targeting of liposomes was described in 1980. The Sustained release drug delivery efficacy of the liposomal formulation depends on Liposomes can be used to provide a sustained its ability to deliver the drug molecule to the release of drugs. provided the original work is properly cited. the liposome can accommodate peptide derivatives were formulated as liposomes antigens in the aqueous cavity or incorporate and administered systemically
REVIEW Open Access Liposomal delivery systems for intestinal lymphatic drug transport Hyeji Ahn and Ji-Ho Park* Abstract Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in REVIEW Open Access Liposomal delivery systems for intestinal lymphatic drug transport Hyeji Ahn and Ji-Ho Park* Abstract Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in
In 2012 the first report on bio-mimetic drug delivery nano systems was published In 2015 ThermoDox (thermosensitive liposomal doxorubicin) was evaluated in clinical trials (Phase III). 22/02/2013 · Thus, much attention on the use of drug delivery systems is focused on overcoming these problems, ultimately leading to the induction of maximal ability of anti-cancer drug. In this respect, a new model for cancer therapy using a novel drug delivery system, fusogenic liposome [ 45 ], …
Background: In this review article, authors reviewed about the liposomes which are amongst various drug delivering systems for the delivery of the therapeutic agents at the target site. Methods: Advances in liposomal drug delivery systems for the cancer therapy have enhanced the therapeutic levels Liposomes are the simple microscopic vesicles in which aqueous layer is enclosed by phospho lipid bilayers that are used to transfer vaccines ,drugs ,enzymes and other substances to targetcells or organs Structually ,liposomes are concentric bilayerd vesicles in which an aqueous volume is entirely enclosed by a membraneous lipid bilayer mainly composed of natural or synthetic phospholipids
DOI: 10.4103/2230-973X.96920. Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Conventional liposomal drug delivery has been hampered by short circulation time in blood due to the preferential accumulation of liposomes in organs of RES. In an effort to address this problem, various surface modifying molecules were investigated including synthetic or natural polymers and oligosaccharides, etc. Among these molecules, PEG (PEG, av. MW 2000–5000 Da) is known to be …
